Added: Annabelle Chavez - Date: 16.12.2021 04:43 - Views: 41335 - Clicks: 1085
Various drugs have been used for the treatment of opioid withdrawal, e. Tramadol is a centrally acting synthetic analgesic agent with opiate activity due to low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to mu opioid receptors. As a consequence, there may be a role for the use of tramadol in the treatment of opiate withdrawal. We attempt to assess the efficacy of tramadol in treating Does tramadol stop opiate withdrawal heroin withdrawal through a retrospective cohort control study, conducted in a detoxification unit in a community teaching hospital.
Out of heroin abusers admitted for detoxification during the review period, 64 patients who were treated either with buprenorphine or tramadol, were included in this study, with 20 participants in the buprenorphine group and 44 in the tramadol group. Both groups were matched for age, sex, and self-reported average quantity of heroin used per day. In the tramadol group, the average CINA maximum was 9. The use of oral clonidine per patient in the tramadol group was 1. The length of stay was 3.
Four participants in the tramadol group received three or more doses of buprenorphine because their symptoms were not controlled, and were considered as treatment failures.
These preliminary data suggest that tramadol may be comparable to buprenorphine in the management of mild to moderately severe heroin withdrawal. These findings, if reproduced in larger studies with stronger research des, have potentially great implications for the management of opioid withdrawal in both the inpatient and outpatient setting. Please enable it to take advantage of the complete set of features!
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of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Cite Display options Display options. Abstract Various drugs have been used for the treatment of opioid withdrawal, e. Comment in The emperor' s new clothes. Schnoll SH. J Addict Dis. PMID: No abstract available. Dunn KE, et al. JAMA Psychiatry. Clinical Trial. Tramadol versus buprenorphine for the management of acute heroin withdrawal: a retrospective matched cohort controlled study. Threlkeld M, et al. Am J Addict. PMID: Comparison of efficacy between buprenorphine and tramadol in the detoxification of opioid heroin -dependent subjects.
Chawla JM, et al. J Opioid Manag. Pharmacological therapies for management of opium withdrawal. Rahimi-Movaghar A, et al. Cochrane Database Syst Rev. Buprenorphine for managing opioid withdrawal. Gowing L, et al. See all similar articles. Shah K, et al. Balhara YPS, Does tramadol stop opiate withdrawal al. J Neurosci Rural Pract. Trial of tramadol plus gabapentin for opioid detoxification. Ziaaddini H, et al. Iran Red Crescent Med J. Time dependent antinociceptive effects of morphine and tramadol in the hot plate test: using different methods of drug administration in female rats.
Gholami M, et al. Iran J Pharm Res. See all "Cited by" articles. Publication types Clinical Trial Actions. Comparative Study Actions. Research Support, Non-U. Gov't Actions. Research Support, U. Gov't, Non-P. Gov't, P. MeSH terms Adult Actions. Cohort Studies Actions. Female Actions. Humans Actions. Male Actions.
Retrospective Studies Actions. Substances Analgesics, Opioid Actions. Narcotic Antagonists Actions. Tramadol Actions. Buprenorphine Actions. Copy Download.Does tramadol stop opiate withdrawal
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Tramadol for the Management of Opioid Withdrawal: A Systematic Review of Randomized Clinical Trials